Published Work

*corresponding author; #co-first author

Selected Publications

Soma S, Hayatsu N, Nomura K, Sherwood MW, Murakami T, Sugiyama Y, Suematsu N, Aoki T, Yamada Y, Asayama M, Kaneko M, Ohbayashi K, Arizono M, Ohtsuka M, Hamada S, Matsumoto I, Iwasaki Y, Ohno N, Okazaki Y, Taruno A*. Channel synapse mediates neurotransmission of airway protective chemoreflexes. Cell 2025. DOI: 10.1016/j.cell.2025.03.007
Taruno A*, Gordon MD. Molecular and cellular mechanisms of salt taste. Annu Rev Physiol 85:25, 2023.
Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A*, Nureki O*: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.
Nomura K#, Nakanishi M, Ishidate F, Iwata K, Taruno A#,*: All-electrical Ca2+-independent signal transduction mediates attractive sodium taste in taste buds. Neuron 2020, 106:815-829. Selected for the journal cover. Faculty Opinions recommended.
Ma Z#, Taruno A#, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff Het al: CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron 2018, 98(3):547-561 e510. Faculty Opinions recommended.
Taruno A*, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y: Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. J Physiol 2017, 595(18):6121-6145.
Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy Met al: CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 2013, 495(7440):223-226. Faculty Opinions recommended.

All Publications

Soma S, Hayatsu N, Nomura K, Sherwood MW, Murakami T, Sugiyama Y, Suematsu N, Aoki T, Yamada Y, Asayama M, Kaneko M, Ohbayashi K, Arizono M, Ohtsuka M, Hamada S, Matsumoto I, Iwasaki Y, Ohno N, Okazaki Y, Taruno A*. Channel synapse mediates neurotransmission of airway protective chemoreflexes. Cell 2025. DOI: 10.1016/j.cell.2025.03.007
Taruno A*: Shared gustatory sensor for acids and ammonium. Trends Neurosci, 47(3):163-164, 2024.
Adams JC, Price OJ, Rogers N, Rounds S, Taruno A, Theiss AL, Uchida S, Wright DC: Physiological Reports celebrates its first 10 years. Physiol Rep 11:e15874, 2023.
Minami Y, Hoshino A, Higuchi Y, Hamaguchi M, Kaneko Y, Kirita Y, Kaminishi S, Nishiki T, Taruno A, Fukui M et al: Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion. Nat Commun 14:4084, 2023.
Taruno A*, Gordon MD: Molecular and cellular mechanisms of salt taste. Annu Rev Physiol 85:25, 2023.
Matsuo M, Seo K, Taruno A, Mizoro Y, Yamaguchi Y, Doi M, Nakao R, Kori H, Abe T, Ohmori H, Tominaga K, Okamura H: A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels. Cell Rep 2022, 39:110844.
Okui M#, Murakami T#, Sun H, Ikeshita C, Kanamura N, Taruno A*: Posttranslational regulation of CALHM1/3 channel: N-linked glycosylation and S-palmitoylation. FASEB J 2021, 35(5):e21527.
Taruno A*, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK: Taste transduction and channel synapses in taste buds. Pflugers Arch 2021, 473(1):3-13. Faculty Opinions recommended.
Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A*, Nureki O*: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.
Nomura K#, Nakanishi M, Ishidate F, Iwata K, Taruno A#,*: All-electrical Ca2+-independent signal transduction mediates attractive sodium taste in taste buds. Neuron 2020, 106:815-829. Selected for the journal cover. Faculty Opinions recommended.
Taruno A*, Kashio M: AAV-Mediated Gene Delivery to Taste Cells of the Tongue. Methods Mol Biol 2019,1950:299-307.
Kashio M, Wei-Qi G, Ohsaki Y, Kido MA, Taruno A*: CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells. Sci Rep 2019,9(1):2681.
Taruno A*: ATP Release Channels. Int J Mol Sci 2018, 19(3).
Ma Z#, Taruno A#, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H et al: CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron 2018, 98(3):547-561 e510. Faculty Opinions recommended.
Mura E#, Taruno A#, Yagi M, Yokota K, Hayashi Y: Innate and acquired tolerance to bitter stimuli in mice. PLoS One 2018, 13(12):e0210032.
Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi Met al: The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease. Free Radic Biol Med 2018, 115:412-420.
Marunaka Y, Niisato N, Miyazaki H, Nakajima KI, Taruno A, Sun H, Marunaka R, Okui M, Yamamoto T, Kanamura Net al: Quercetin is a Useful Medicinal Compound Showing Various Actions Including Control of Blood Pressure, Neurite Elongation and Epithelial Ion Transport. Curr Med Chem 2018, 25(37):4876-4887.
Marunaka R#, Taruno A#, Yamamoto T, Kanamura N, Marunaka Y: Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model. Cell Physiol Biochem 2018, 50(1):363-377.
Taruno A*, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y: Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. J Physiol 2017, 595(18):6121-6145.
Taruno A*, Marunaka Y: Hypotonicity activates a voltage-dependent membrane conductance in N2a neuroblastoma cells. Biochem Biophys Res Commun 2017, 484(2):331-335.
Taruno A*, Kashio M, Sun H, Kobayashi K, Sano H, Nambu A, Marunaka Y: Adeno-Associated Virus-Mediated Gene Transfer into Taste Cells In Vivo. Chem Senses 2017, 42(1):69-78. Selected for the journal cover.
Sasamoto K, Marunaka R, Niisato N, Sun H, Taruno A, Pezzotti G#, Yamamoto T, Kanamura N, Zhu W, Nishio Ket al: Analysis of Aprotinin, a Protease Inhibitor, Action on the Trafficking of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells Using a Mathematical Model. Cell Physiol Biochem 2017, 41(5):1865-1880.
Nomura T#, Taruno A#, Shiraishi M, Nakahari T, Inui T, Sokabe M, Eaton DC, Marunaka Y: Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics. Sci Rep 2017, 7(1):10512.
Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, Taruno A: Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules 2017, 22(2).
Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Taruno A: Na(+) homeostasis by epithelial Na(+) channel (ENaC) and Nax channel (Nax): cooperation of ENaC and Nax. Ann Transl Med 2016, 4(Suppl 1):S11.
Ma Z, Tanis JE, Taruno A, Foskett JK: Calcium homeostasis modulator (CALHM) ion channels. Pflugers Arch 2016, 468(3):395-403.
Sasamoto K, Niisato N, Taruno A, Marunaka Y: Simulation of Cl(-) Secretion in Epithelial Tissues: New Methodology Estimating Activity of Electro-Neutral Cl(-) Transporter. Front Physiol 2015, 6:370.
Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy M et al: CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 2013, 495(7440):223-226. Faculty Opinions recommended.
Taruno A*, Matsumoto I, Ma Z, Marambaud P, Foskett JK: How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel. Bioessays 2013, 35(12):1111-1118.
Taruno A, Ohmori H, Kuba H: Inhibition of presynaptic Na(+)/K(+)-ATPase reduces readily releasable pool size at the avian end-bulb of Held synapse. Neurosci Res 2012, 72(2):117-128.
Marunaka Y, Niisato N, Taruno A, Ohta M, Miyazaki H, Hosogi S, Nakajima K, Kusuzaki K, Ashihara E, Nishio K et al: Regulation of epithelial sodium transport via epithelial Na+ channel. J Biomed Biotechnol 2011, 2011:978196.
Taruno A, Marunaka Y: Analysis of blocker-labeled channels reveals the dependence of recycling rates of ENaC on the total amount of recycled channels. Cell Physiol Biochem 2010, 26(6):925-934.
Tokuda S, Niisato N, Nagai T, Taruno A, Nakajima K, Miyazaki H, Yamada T, Hosogi S, Ohta M, Nishio K et al: Regulation of paracellular Na+ and Cl(-) conductances by hydrostatic pressure. Cell Biol Int 2009, 33(9):949-956.
Taruno A, Niisato N, Marunaka Y: Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells. Am J Physiol Renal Physiol 2008, 294(1):F177-186.
Taruno A, Niisato N, Marunaka Y: Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases. Am J Physiol Renal Physiol 2007, 293(1):F128-138.
Niisato N#, Taruno A#, Marunaka Y: Aldosterone-induced modification of osmoregulated ENaC trafficking. Biochem Biophys Res Commun 2007, 361(1):162-168.
Niisato N, Taruno A, Marunaka Y: Involvement of p38 MAPK in hypotonic stress-induced stimulation of beta- and gamma-ENaC expression in renal epithelium. Biochem Biophys Res Commun 2007, 358(3):819-824.
Niisato N, Hasegawa I, Tokuda S, Taruno A, Nakajima K, Miyazaki H, Iwasaki Y, Marunaka Y: Action of neltenexine on anion secretion in human airway epithelia. Biochem Biophys Res Commun 2007, 356(4):1050-1055.

Publications: Publications

Published Work

​*corresponding author; #co-first author

​

Selected Publications

Taruno A*, Gordon MD. Molecular and cellular mechanisms of salt taste. Annu Rev Physiol 85:25, 2023.

Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A*, Nureki O*: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.

Nomura K#, Nakanishi M, Ishidate F, Iwata K, Taruno A#,*: All-electrical Ca2+-independent signal transduction mediates attractive sodium taste in taste buds. Neuron 2020, 106:815-829. Selected for the journal cover. Faculty Opinions recommended.

Ma Z#, Taruno A#, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff Het al: CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron 2018, 98(3):547-561 e510. Faculty Opinions recommended.

Taruno A*, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y: Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. J Physiol 2017, 595(18):6121-6145.

Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy Met al: CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 2013, 495(7440):223-226. Faculty Opinions recommended.

​

All Publications

Taruno A*: Shared gustatory sensor for acids and ammonium. Trends Neurosci, 47(3):163-164, 2024.

Adams JC, Price OJ, Rogers N, Rounds S, Taruno A, Theiss AL, Uchida S, Wright DC: Physiological Reports celebrates its first 10 years. Physiol Rep 11:e15874, 2023.

Minami Y, Hoshino A, Higuchi Y, Hamaguchi M, Kaneko Y, Kirita Y, Kaminishi S, Nishiki T, Taruno A, Fukui M et al: Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion. Nat Commun 14:4084, 2023.

Taruno A*, Gordon MD: Molecular and cellular mechanisms of salt taste. Annu Rev Physiol 85:25, 2023.

Matsuo M, Seo K, Taruno A, Mizoro Y, Yamaguchi Y, Doi M, Nakao R, Kori H, Abe T, Ohmori H, Tominaga K, Okamura H: A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels. Cell Rep 2022, 39:110844.

Okui M#, Murakami T#, Sun H, Ikeshita C, Kanamura N, Taruno A*: Posttranslational regulation of CALHM1/3 channel: N-linked glycosylation and S-palmitoylation. FASEB J 2021, 35(5):e21527.

Taruno A*, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK: Taste transduction and channel synapses in taste buds. Pflugers Arch 2021, 473(1):3-13. Faculty Opinions recommended.

Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A*, Nureki O*: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.

Nomura K#, Nakanishi M, Ishidate F, Iwata K, Taruno A#,*: All-electrical Ca2+-independent signal transduction mediates attractive sodium taste in taste buds. Neuron 2020, 106:815-829. Selected for the journal cover. Faculty Opinions recommended.

Taruno A*, Kashio M: AAV-Mediated Gene Delivery to Taste Cells of the Tongue. Methods Mol Biol 2019,1950:299-307.

Kashio M, Wei-Qi G, Ohsaki Y, Kido MA, Taruno A*: CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells. Sci Rep 2019,9(1):2681.

Taruno A*: ATP Release Channels. Int J Mol Sci 2018, 19(3).

Ma Z#, Taruno A#, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H et al: CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron 2018, 98(3):547-561 e510. Faculty Opinions recommended.

Mura E#, Taruno A#, Yagi M, Yokota K, Hayashi Y: Innate and acquired tolerance to bitter stimuli in mice. PLoS One 2018, 13(12):e0210032.

Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi Met al: The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease. Free Radic Biol Med 2018, 115:412-420.

Marunaka R#, Taruno A#, Yamamoto T, Kanamura N, Marunaka Y: Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model. Cell Physiol Biochem 2018, 50(1):363-377.

Taruno A*, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y: Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. J Physiol 2017, 595(18):6121-6145.

Taruno A*, Marunaka Y: Hypotonicity activates a voltage-dependent membrane conductance in N2a neuroblastoma cells. Biochem Biophys Res Commun 2017, 484(2):331-335.

Taruno A*, Kashio M, Sun H, Kobayashi K, Sano H, Nambu A, Marunaka Y: Adeno-Associated Virus-Mediated Gene Transfer into Taste Cells In Vivo. Chem Senses 2017, 42(1):69-78. Selected for the journal cover.

Nomura T#, Taruno A#, Shiraishi M, Nakahari T, Inui T, Sokabe M, Eaton DC, Marunaka Y: Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics. Sci Rep 2017, 7(1):10512.

Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, Taruno A: Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules 2017, 22(2).

Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Taruno A: Na(+) homeostasis by epithelial Na(+) channel (ENaC) and Nax channel (Nax): cooperation of ENaC and Nax. Ann Transl Med 2016, 4(Suppl 1):S11.

Ma Z, Tanis JE, Taruno A, Foskett JK: Calcium homeostasis modulator (CALHM) ion channels. Pflugers Arch 2016, 468(3):395-403.

Sasamoto K, Niisato N, Taruno A, Marunaka Y: Simulation of Cl(-) Secretion in Epithelial Tissues: New Methodology Estimating Activity of Electro-Neutral Cl(-) Transporter. Front Physiol 2015, 6:370.

Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy M et al: CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 2013, 495(7440):223-226. Faculty Opinions recommended.

Taruno A*, Matsumoto I, Ma Z, Marambaud P, Foskett JK: How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel. Bioessays 2013, 35(12):1111-1118.

Taruno A, Ohmori H, Kuba H: Inhibition of presynaptic Na(+)/K(+)-ATPase reduces readily releasable pool size at the avian end-bulb of Held synapse. Neurosci Res 2012, 72(2):117-128.

Marunaka Y, Niisato N, Taruno A, Ohta M, Miyazaki H, Hosogi S, Nakajima K, Kusuzaki K, Ashihara E, Nishio K et al: Regulation of epithelial sodium transport via epithelial Na+ channel. J Biomed Biotechnol 2011, 2011:978196.

Taruno A, Marunaka Y: Analysis of blocker-labeled channels reveals the dependence of recycling rates of ENaC on the total amount of recycled channels. Cell Physiol Biochem 2010, 26(6):925-934.

Tokuda S, Niisato N, Nagai T, Taruno A, Nakajima K, Miyazaki H, Yamada T, Hosogi S, Ohta M, Nishio K et al: Regulation of paracellular Na+ and Cl(-) conductances by hydrostatic pressure. Cell Biol Int 2009, 33(9):949-956.

Taruno A, Niisato N, Marunaka Y: Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells. Am J Physiol Renal Physiol 2008, 294(1):F177-186.

Taruno A, Niisato N, Marunaka Y: Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases. Am J Physiol Renal Physiol 2007, 293(1):F128-138.

Niisato N#, Taruno A#, Marunaka Y: Aldosterone-induced modification of osmoregulated ENaC trafficking. Biochem Biophys Res Commun 2007, 361(1):162-168.

Niisato N, Taruno A, Marunaka Y: Involvement of p38 MAPK in hypotonic stress-induced stimulation of beta- and gamma-ENaC expression in renal epithelium. Biochem Biophys Res Commun 2007, 358(3):819-824.

Niisato N, Hasegawa I, Tokuda S, Taruno A, Nakajima K, Miyazaki H, Iwasaki Y, Marunaka Y: Action of neltenexine on anion secretion in human airway epithelia. Biochem Biophys Res Commun 2007, 356(4):1050-1055.

*corresponding author; #co-first author

Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A, Nureki O: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.

Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A, Nureki O: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.