Published Work

*corresponding author; #co-first author

Selected Publications

Taruno A*, Gordon MD. Molecular and cellular mechanisms of salt taste. Annu Rev Physiol, 85:25, 2023.
Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A*, Nureki O*: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.
Nomura K#, Nakanishi M, Ishidate F, Iwata K, Taruno A#,*: All-electrical Ca2+-independent signal transduction mediates attractive sodium taste in taste buds. Neuron 2020, 106:815-829. Selected for the journal cover. Faculty Opinions recommended.
Ma Z#, Taruno A#, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff Het al: CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron 2018, 98(3):547-561 e510. Faculty Opinions recommended.
Taruno A*, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y: Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. J Physiol 2017, 595(18):6121-6145.
Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy Met al: CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 2013, 495(7440):223-226. Faculty Opinions recommended.

All Publications

Taruno A*, Gordon MD. Molecular and cellular mechanisms of salt taste. Annu Rev Physiol, 85:25, 2023.
Matsuo M, Seo K, Taruno A, Mizoro Y, Yamaguchi Y, Doi M, Nakao R, Kori H, Abe T, Ohmori H, Tominaga K, Okamura H. A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels. Cell Rep 2022, 39:110844.
Okui M#, Murakami T#, Sun H, Ikeshita C, Kanamura N, Taruno A*. Posttranslational regulation of CALHM1/3 channel: N-linked glycosylation and S-palmitoylation. FASEB J 2021, 35(5):e21527.
Taruno A*, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK: Taste transduction and channel synapses in taste buds. Pflugers Arch 2021, 473(1):3-13. Faculty Opinions recommended.
Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A*, Nureki O*: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.
Nomura K#, Nakanishi M, Ishidate F, Iwata K, Taruno A#,*: All-electrical Ca2+-independent signal transduction mediates attractive sodium taste in taste buds. Neuron 2020, 106:815-829. Selected for the journal cover. Faculty Opinions recommended.
Taruno A*, Kashio M: AAV-Mediated Gene Delivery to Taste Cells of the Tongue. Methods Mol Biol 2019,1950:299-307.
Kashio M, Wei-Qi G, Ohsaki Y, Kido MA, Taruno A*: CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells. Sci Rep 2019,9(1):2681.
Taruno A*: ATP Release Channels. Int J Mol Sci 2018, 19(3).
Ma Z#, Taruno A#, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff Het al: CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron 2018, 98(3):547-561 e510. Faculty Opinions recommended.
Mura E#, Taruno A#, Yagi M, Yokota K, Hayashi Y: Innate and acquired tolerance to bitter stimuli in mice. PLoS One 2018, 13(12):e0210032.
Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi Met al: The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease. Free Radic Biol Med 2018, 115:412-420.
Marunaka Y, Niisato N, Miyazaki H, Nakajima KI, Taruno A, Sun H, Marunaka R, Okui M, Yamamoto T, Kanamura Net al: Quercetin is a Useful Medicinal Compound Showing Various Actions Including Control of Blood Pressure, Neurite Elongation and Epithelial Ion Transport. Curr Med Chem 2018, 25(37):4876-4887.
Marunaka R#, Taruno A#, Yamamoto T, Kanamura N, Marunaka Y: Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model. Cell Physiol Biochem 2018, 50(1):363-377.
Taruno A*, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y: Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. J Physiol 2017, 595(18):6121-6145.
Taruno A*, Marunaka Y: Hypotonicity activates a voltage-dependent membrane conductance in N2a neuroblastoma cells. Biochem Biophys Res Commun 2017, 484(2):331-335.
Taruno A*, Kashio M, Sun H, Kobayashi K, Sano H, Nambu A, Marunaka Y: Adeno-Associated Virus-Mediated Gene Transfer into Taste Cells In Vivo. Chem Senses 2017, 42(1):69-78. Selected for the journal cover.
Sasamoto K, Marunaka R, Niisato N, Sun H, Taruno A, Pezzotti G#, Yamamoto T, Kanamura N, Zhu W, Nishio Ket al: Analysis of Aprotinin, a Protease Inhibitor, Action on the Trafficking of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells Using a Mathematical Model. Cell Physiol Biochem 2017, 41(5):1865-1880.
Nomura T#, Taruno A#, Shiraishi M, Nakahari T, Inui T, Sokabe M, Eaton DC, Marunaka Y: Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics. Sci Rep 2017, 7(1):10512.
Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, Taruno A: Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules 2017, 22(2).
Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Taruno A: Na(+) homeostasis by epithelial Na(+) channel (ENaC) and Nax channel (Nax): cooperation of ENaC and Nax. Ann Transl Med 2016, 4(Suppl 1):S11.
Ma Z, Tanis JE, Taruno A, Foskett JK: Calcium homeostasis modulator (CALHM) ion channels. Pflugers Arch 2016, 468(3):395-403.
Sasamoto K, Niisato N, Taruno A, Marunaka Y: Simulation of Cl(-) Secretion in Epithelial Tissues: New Methodology Estimating Activity of Electro-Neutral Cl(-) Transporter. Front Physiol 2015, 6:370.
Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy Met al: CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 2013, 495(7440):223-226. Faculty Opinions recommended.
Taruno A*, Matsumoto I, Ma Z, Marambaud P, Foskett JK: How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel. Bioessays 2013, 35(12):1111-1118.
Taruno A, Ohmori H, Kuba H: Inhibition of presynaptic Na(+)/K(+)-ATPase reduces readily releasable pool size at the avian end-bulb of Held synapse. Neurosci Res 2012, 72(2):117-128.
Marunaka Y, Niisato N, Taruno A, Ohta M, Miyazaki H, Hosogi S, Nakajima K, Kusuzaki K, Ashihara E, Nishio Ket al: Regulation of epithelial sodium transport via epithelial Na+ channel. J Biomed Biotechnol 2011, 2011:978196.
Taruno A, Marunaka Y: Analysis of blocker-labeled channels reveals the dependence of recycling rates of ENaC on the total amount of recycled channels. Cell Physiol Biochem 2010, 26(6):925-934.
Tokuda S, Niisato N, Nagai T, Taruno A, Nakajima K, Miyazaki H, Yamada T, Hosogi S, Ohta M, Nishio Ket al: Regulation of paracellular Na+ and Cl(-) conductances by hydrostatic pressure. Cell Biol Int 2009, 33(9):949-956.
Taruno A, Niisato N, Marunaka Y: Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells. Am J Physiol Renal Physiol 2008, 294(1):F177-186.
Taruno A, Niisato N, Marunaka Y: Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases. Am J Physiol Renal Physiol 2007, 293(1):F128-138.
Niisato N#, Taruno A#, Marunaka Y: Aldosterone-induced modification of osmoregulated ENaC trafficking. Biochem Biophys Res Commun 2007, 361(1):162-168.
Niisato N, Taruno A, Marunaka Y: Involvement of p38 MAPK in hypotonic stress-induced stimulation of beta- and gamma-ENaC expression in renal epithelium. Biochem Biophys Res Commun 2007, 358(3):819-824.
Niisato N, Hasegawa I, Tokuda S, Taruno A, Nakajima K, Miyazaki H, Iwasaki Y, Marunaka Y: Action of neltenexine on anion secretion in human airway epithelia. Biochem Biophys Res Commun 2007, 356(4):1050-1055.

Publications: Publications

Published Work

​*corresponding author; #co-first author

​

Selected Publications

Taruno A*, Gordon MD. Molecular and cellular mechanisms of salt taste. Annu Rev Physiol, 85:25, 2023.

Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A*, Nureki O*: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.

Nomura K#, Nakanishi M, Ishidate F, Iwata K, Taruno A#,*: All-electrical Ca2+-independent signal transduction mediates attractive sodium taste in taste buds. Neuron 2020, 106:815-829. Selected for the journal cover. Faculty Opinions recommended.

Ma Z#, Taruno A#, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff Het al: CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron 2018, 98(3):547-561 e510. Faculty Opinions recommended.

Taruno A*, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y: Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. J Physiol 2017, 595(18):6121-6145.

Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy Met al: CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 2013, 495(7440):223-226. Faculty Opinions recommended.

​

All Publications

Taruno A*, Gordon MD. Molecular and cellular mechanisms of salt taste. Annu Rev Physiol, 85:25, 2023.

Matsuo M, Seo K, Taruno A, Mizoro Y, Yamaguchi Y, Doi M, Nakao R, Kori H, Abe T, Ohmori H, Tominaga K, Okamura H. A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels. Cell Rep 2022, 39:110844.

Okui M#, Murakami T#, Sun H, Ikeshita C, Kanamura N, Taruno A*. Posttranslational regulation of CALHM1/3 channel: N-linked glycosylation and S-palmitoylation. FASEB J 2021, 35(5):e21527.

Taruno A*, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK: Taste transduction and channel synapses in taste buds. Pflugers Arch 2021, 473(1):3-13. Faculty Opinions recommended.

Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A*, Nureki O*: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.

Nomura K#, Nakanishi M, Ishidate F, Iwata K, Taruno A#,*: All-electrical Ca2+-independent signal transduction mediates attractive sodium taste in taste buds. Neuron 2020, 106:815-829. Selected for the journal cover. Faculty Opinions recommended.

Taruno A*, Kashio M: AAV-Mediated Gene Delivery to Taste Cells of the Tongue. Methods Mol Biol 2019,1950:299-307.

Kashio M, Wei-Qi G, Ohsaki Y, Kido MA, Taruno A*: CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells. Sci Rep 2019,9(1):2681.

Taruno A*: ATP Release Channels. Int J Mol Sci 2018, 19(3).

Ma Z#, Taruno A#, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff Het al: CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron 2018, 98(3):547-561 e510. Faculty Opinions recommended.

Mura E#, Taruno A#, Yagi M, Yokota K, Hayashi Y: Innate and acquired tolerance to bitter stimuli in mice. PLoS One 2018, 13(12):e0210032.

Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi Met al: The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease. Free Radic Biol Med 2018, 115:412-420.

Marunaka R#, Taruno A#, Yamamoto T, Kanamura N, Marunaka Y: Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model. Cell Physiol Biochem 2018, 50(1):363-377.

Taruno A*, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y: Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. J Physiol 2017, 595(18):6121-6145.

Taruno A*, Marunaka Y: Hypotonicity activates a voltage-dependent membrane conductance in N2a neuroblastoma cells. Biochem Biophys Res Commun 2017, 484(2):331-335.

Taruno A*, Kashio M, Sun H, Kobayashi K, Sano H, Nambu A, Marunaka Y: Adeno-Associated Virus-Mediated Gene Transfer into Taste Cells In Vivo. Chem Senses 2017, 42(1):69-78. Selected for the journal cover.

Nomura T#, Taruno A#, Shiraishi M, Nakahari T, Inui T, Sokabe M, Eaton DC, Marunaka Y: Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics. Sci Rep 2017, 7(1):10512.

Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, Taruno A: Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules 2017, 22(2).

Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Taruno A: Na(+) homeostasis by epithelial Na(+) channel (ENaC) and Nax channel (Nax): cooperation of ENaC and Nax. Ann Transl Med 2016, 4(Suppl 1):S11.

Ma Z, Tanis JE, Taruno A, Foskett JK: Calcium homeostasis modulator (CALHM) ion channels. Pflugers Arch 2016, 468(3):395-403.

Sasamoto K, Niisato N, Taruno A, Marunaka Y: Simulation of Cl(-) Secretion in Epithelial Tissues: New Methodology Estimating Activity of Electro-Neutral Cl(-) Transporter. Front Physiol 2015, 6:370.

Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy Met al: CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 2013, 495(7440):223-226. Faculty Opinions recommended.

Taruno A*, Matsumoto I, Ma Z, Marambaud P, Foskett JK: How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel. Bioessays 2013, 35(12):1111-1118.

Taruno A, Ohmori H, Kuba H: Inhibition of presynaptic Na(+)/K(+)-ATPase reduces readily releasable pool size at the avian end-bulb of Held synapse. Neurosci Res 2012, 72(2):117-128.

Marunaka Y, Niisato N, Taruno A, Ohta M, Miyazaki H, Hosogi S, Nakajima K, Kusuzaki K, Ashihara E, Nishio Ket al: Regulation of epithelial sodium transport via epithelial Na+ channel. J Biomed Biotechnol 2011, 2011:978196.

Taruno A, Marunaka Y: Analysis of blocker-labeled channels reveals the dependence of recycling rates of ENaC on the total amount of recycled channels. Cell Physiol Biochem 2010, 26(6):925-934.

Tokuda S, Niisato N, Nagai T, Taruno A, Nakajima K, Miyazaki H, Yamada T, Hosogi S, Ohta M, Nishio Ket al: Regulation of paracellular Na+ and Cl(-) conductances by hydrostatic pressure. Cell Biol Int 2009, 33(9):949-956.

Taruno A, Niisato N, Marunaka Y: Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells. Am J Physiol Renal Physiol 2008, 294(1):F177-186.

Taruno A, Niisato N, Marunaka Y: Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases. Am J Physiol Renal Physiol 2007, 293(1):F128-138.

Niisato N#, Taruno A#, Marunaka Y: Aldosterone-induced modification of osmoregulated ENaC trafficking. Biochem Biophys Res Commun 2007, 361(1):162-168.

Niisato N, Taruno A, Marunaka Y: Involvement of p38 MAPK in hypotonic stress-induced stimulation of beta- and gamma-ENaC expression in renal epithelium. Biochem Biophys Res Commun 2007, 358(3):819-824.

Niisato N, Hasegawa I, Tokuda S, Taruno A, Nakajima K, Miyazaki H, Iwasaki Y, Marunaka Y: Action of neltenexine on anion secretion in human airway epithelia. Biochem Biophys Res Commun 2007, 356(4):1050-1055.

*corresponding author; #co-first author

Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A, Nureki O: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.

Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A, Nureki O: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv 2020, 6:eaba8105.